Antineutrophil Cytoplasmic Antibodies (ANCA)

How to Cite This Chapter: Don-Wauchope A, Chetty VT, Ivica J, Kavsak P, Khan WI, Lafreniere M, Nouri K, Solnica B. Antineutrophil Cytoplasmic Antibodies (ANCA). McMaster Textbook of Internal Medicine. Kraków: Medycyna Praktyczna. https://empendium.com/mcmtextbook/chapter/B31.1269.3.7.129.?utm_source=nieznany&utm_medium=referral&utm_campaign=social-chapter-link Accessed December 12, 2024.
Last Updated: May 9, 2022
Last Reviewed: May 9, 2022
Chapter Information

For a brief introduction and guide to abbreviations, see Laboratory Tests: General Remarks.

Analyte [material]

Antineutrophil cytoplasmic antibodies (ANCA) [S/P]

Reference range, target level, or decision threshold

Titer <1:10-1:20 (depending on method)!!!

Interpretation of results

c-ANCA: Granulomatosis with polyangiitis, microscopic polyangiitis, eosinophilic granulomatosis with polyangiitis, subacute glomerulonephritis

p-ANCA: Microscopic polyangiitis, eosinophilic granulomatosis with polyangiitis, subacute glomerulonephritis, granulomatosis with polyangiitis, drug-induced immune response, ulcerative colitis, Crohn disease, autoimmune liver diseases, systemic connective tissue diseases, HIV infection

ANCAs are present in autoimmune vasculitis, including Wegener granulomatosis and microscopic polyangiitis; c-ANCAs, in Wegener granulomatosis; p-ANCAs, predominately in microscopic polyangiitis. Negative ANCA results do not exclude ANCA-associated vasculitis or irritable bowel disease.

We would love to hear from you

Comments, mistakes, suggestions?

We use cookies to ensure you get the best browsing experience on our website. Refer to our Cookies Information and Privacy Policy for more details.