Monoclonal Immunoglobulin Deposition Disease

Chapter: Monoclonal Immunoglobulin Deposition Disease
McMaster Section Editor(s): Christine M. Ribic, Karen C.Y. To
Section Editor(s) in Interna Szczeklika: Franciszek Kokot, Robert Drabczyk
McMaster Author(s): Matthew Miller
Author(s) in Interna Szczeklika: Zbigniew Hruby, Robert Drabczyk
Additional Information

Glomerulopathy in monoclonal immunoglobulin deposition disease (MIDD) develops as a result of granular deposition of subunits of monoclonal immunoglobulins, which can be light chain, heavy chain, or both, with the subsequent development of nodular glomerulosclerosis. These deposits differ from amyloid deposits (see Renal Amyloidosis) by negative metachromatic staining on immunofluorescence and random rather than organized arrangement.

The disease is caused by monoclonal gammopathies and occurs in approximately 5% of patients with multiple myeloma.

Renal involvement presents as renal insufficiency and proteinuria of varying degrees. It may improve with effective therapy.


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