Kidney Disease: Improving Global Outcomes (KDIGO) Glomerulonephritis Work Group. KDIGO Clinical Practice Guideline for Glomerulonephritis. Kidney inter., Suppl. 2012; 2: 139–274.
Bertsias GK, Tektonidou M, Amoura Z, et al; European League Against Rheumatism and European Renal Association-European Dialysis and Transplant Association. Joint European League Against Rheumatism and European Renal Association-European Dialysis and Transplant Association (EULAR/ERA-EDTA) recommendations for the management of adult and paediatric lupus nephritis. Ann Rheum Dis. 2012 Nov;71(11):1771-82. doi: 10.1136/annrheumdis-2012-201940. Epub 2012 Jul 31. PubMed PMID: 22851469; PubMed Central PMCID: PMC3465859.
Glomerulopathy in monoclonal immunoglobulin deposition disease (MIDD) develops as a result of granular deposition of subunits of monoclonal immunoglobulins, which can be light chain, heavy chain, or both, with the subsequent development of nodular glomerulosclerosis. These deposits differ from amyloid deposits (see Renal Amyloidosis) by negative metachromatic staining on immunofluorescence and random rather than organized arrangement.
The disease is caused by monoclonal gammopathies and occurs in approximately 5% of patients with multiple myeloma.
Renal involvement presents as renal insufficiency and proteinuria of varying degrees. It may improve with effective therapy.