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Mesangioproliferative glomerulonephritis (GN) is a proliferative GN characterized by diffuse proliferation of mesangial cells with expansion of mesangial matrix.
The dominant clinical features include microscopic hematuria and proteinuria (usually moderate).
The most common primary mesangioproliferative GN is IgA nephropathy. Secondary mesangioproliferative GN/secondary IgA nephropathy is most frequently associated with IgA-related vasculitis (also referred to as Henoch-Schönlein purpura), cirrhosis and other severe liver diseases, celiac disease and other autoimmune conditions, or HIV infection.
Treatment and prognosis are related to the underlying condition.