Thin Basement Membrane Disease

How to Cite This Chapter: Miller M, Klinger M, Drabczyk R. Thin Basement Membrane Disease. McMaster Textbook of Internal Medicine. Kraków: Medycyna Praktyczna. Accessed June 06, 2020.
Last Updated: July 16, 2017
Last Reviewed: July 3, 2019
Chapter Information

Definition, EtiologyTop

Thin basement membrane disease (TBMD) (also called benign familial hematuria) is a congenital glomerulopathy characterized by thinning (<250 nm) of the glomerular basement membrane. Patients with familial TBMD have autosomal dominant inheritance, although they may not have a known family history, given the asymptomatic nature of the condition.

Clinical FeaturesTop

Patients develop microscopic hematuria, which is frequently detectable as early as in childhood. Typically proteinuria and hypertension are absent and patients do not develop renal failure. Hematuria is not aggravated by comorbidities and extrarenal symptoms do not occur.


Diagnosis is based on electron microscopy examination demonstrating thin basement membranes without other pathologies.


Specific treatment is neither available nor necessary.

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