Scully M, Hunt BJ, Benjamin S, et al; British Committee for Standards in Haematology. Guidelines on the diagnosis and management of thrombotic thrombocytopenic purpura and other thrombotic microangiopathies. Br J Haematol. 2012 Aug;158(3):323-35. doi: 10.1111/j.1365-2141.2012.09167.x. Epub 2012 May 25. PubMed PMID: 22624596.
Neunert C, Lim W, Crowther M, Cohen A, Solberg L Jr, Crowther MA; American Society of Hematology. The American Society of Hematology 2011 evidence-based practice guideline for immune thrombocytopenia. Blood. 2011 Apr 21;117(16):4190-207. doi: 10.1182/blood-2010-08-302984. Epub 2011 Feb 16. Review. PubMed PMID: 21325604.
Allford SL, Hunt BJ, Rose P, Machin SJ; Haemostasis and Thrombosis Task Force, British Committee for Standards in Haematology. Guidelines on the diagnosis and management of the thrombotic microangiopathic haemolytic anaemias. Br J Haematol. 2003 Feb;120(4):556-73. PubMed PMID: 12588343.
Thrombocytopenia found in a complete blood count in a patient with a certain clinical condition (causes: see Disorders of Platelets). Bone marrow aspiration and biopsy reveal reduced megakaryocyte counts or their abnormal morphology. Other diagnostic studies depend on the suspected underlying condition.
Repeated platelet transfusion is likely to be associated with refractoriness; thus, transfusion should be used sparingly.
1. Treatment of inherited disease: Platelet concentrate transfusions (see Platelet Concentrate).
2. Treatment of acquired disease: Eliminate the causative factor(s), treat the underlying condition, and administer platelet concentrate when necessary.