Thrombocytopenia Caused by Decreased Platelet Production

Chapter: Thrombocytopenia Caused by Decreased Platelet Production
McMaster Section Editor(s): Mark Crowther
Section Editor(s) in Interna Szczeklika: Andrzej Hellmann, Bogdan Ochrem
McMaster Author(s): Mark Crowther
Author(s) in Interna Szczeklika: Krystyna Zawilska†, Wojciech Młynarski
† Deceased.
Additional Information


Thrombocytopenia found in complete blood count in a patient with a certain clinical condition (causes: see Disorders of Platelets). Bone marrow aspiration and biopsy reveal reduced megakaryocyte counts or their abnormal morphology. Other diagnostic studies depend on the suspected underlying condition.

Treatment Top

Repeated platelet transfusion is likely to be associated with refractoriness; thus, transfusion should be used sparingly.

1. Treatment of inherited disease: Platelet concentrate transfusions.

2. Treatment of acquired disease: Eliminate the causative factor or factors, treat the underlying condition, and administer platelet concentrate when necessary.

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