Thrombocytopenia Caused by Decreased Platelet Production

How to Cite This Chapter: Crowther M, Zawilska K, Młynarski W. Thrombocytopenia Caused by Decreased Platelet Production. McMaster Textbook of Internal Medicine. Kraków: Medycyna Praktyczna. Accessed September 19, 2020.
Last Updated: December 9, 2017
Last Reviewed: May 12, 2019
Chapter Information


Thrombocytopenia found in the complete blood count in a patient with a certain clinical condition (causes: see Platelet Disorders). Bone marrow aspiration and biopsy reveal reduced megakaryocyte counts or their abnormal morphology. Other diagnostic studies depend on the suspected underlying condition.

Treatment Top

Repeated platelet transfusion is likely to be associated with refractoriness; thus, transfusion should be used sparingly.

1. Treatment of inherited disease: Platelet concentrate transfusions.

2. Treatment of acquired disease: Eliminate the causative factor or factors, treat the underlying condition, and administer platelet concentrate when necessary.

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