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Allford SL, Hunt BJ, Rose P, Machin SJ; Haemostasis and Thrombosis Task Force, British Committee for Standards in Haematology. Guidelines on the diagnosis and management of the thrombotic microangiopathic haemolytic anaemias. Br J Haematol. 2003 Feb;120(4):556-73. PubMed PMID: 12588343.
Thrombocytopenia found in the complete blood count in a patient with a certain clinical condition (causes: see Platelet Disorders: General Considerations). Bone marrow aspiration and biopsy reveal reduced megakaryocyte counts or their abnormal morphology. Other diagnostic studies depend on the suspected underlying condition.
Repeated platelet transfusion is likely to be associated with refractoriness; thus, transfusion should be used sparingly.
1. Treatment of inherited disease: Platelet concentrate transfusions.
2. Treatment of acquired disease: Eliminate the causative factor or factors, treat the underlying condition, and administer platelet concentrate when necessary.