Tricuspid Stenosis

Chapter: Tricuspid Stenosis
McMaster Section Editor(s): P.J. Devereaux
Section Editor(s) in Interna Szczeklika: Andrzej Budaj, Wiktoria Leśniak
McMaster Author(s): Omid Salehian
Author(s) in Interna Szczeklika: Marek Konka, Piotr Hoffman
Additional Information

Definition, Etiology, Pathogenesis Top

Tricuspid stenosis (TS) is a reduction of the tricuspid valve orifice area, which causes impaired right ventricular filling.

Etiology: Rheumatic fever; other, very rare etiologies include carcinoid syndrome. Right atrial myxoma or other tumors of the right atrium, tricuspid valve vegetations, and right atrial thrombus can cause tricuspid inflow stenosis not related to the valve but with similar physiologic consequences. Tricuspid atresia is a rare congenital anomaly affecting the tricuspid valve with other associated lesions. Patients with previous tricuspid valve replacement can develop prosthetic valve stenosis. The majority of patients have mixed TS and tricuspid regurgitation (TR), such as those with carcinoid syndrome.

Clinical Features Top

1. Symptoms: Progressive fatigue, loss of appetite, mild dyspnea.

2. Signs: A tricuspid opening snap, presystolic murmur (in patients with sinus rhythm), an early- and mid-diastolic murmur (rarely holodiastolic), most prominent during inspiration; signs of right ventricular failure (see Chronic Heart Failure), pulsations of the liver (presystolic pulsation is typical).

Diagnosis Top

Diagnostic Tests

1. Electrocardiography (ECG): P pulmonale; frequently atrial fibrillation or atrial flutter. There may be features of enlargement of both atria (due to the frequent coexisting mitral valve disease). The amplitude of the QRS complex may be low in V1 due to right atrial enlargement.

2. Chest radiographs: Right atrial enlargement and dilation of the superior vena cava. Pulmonary perfusion may be reduced.

3. Echocardiography: Evaluation of the valve morphology and severity of the defect. A mean transvalvular gradient of ≥5 mm Hg at a normal heart rate is considered indicative of clinically significant TS. Given the association with rheumatic heart disease, the left-sided valve should be fully assessed. In cases of suspected carcinoid syndrome, there is often pulmonary valve involvement with combined stenosis and regurgitation.

Treatment Top

1. Medical treatment: Diuretics (agents: Table 3.9-6; dosage: Table 3.8-4) and fluid and sodium restriction.

2. Invasive treatment should be considered in patients with severe TS who are (1) symptomatic; or (2) undergoing intervention on other left heart valves (percutaneous valvotomy may be attempted in patients eligible for percutaneous mitral commissurotomy). In patients with isolated severe TS, consider percutaneous tricuspid balloon valvotomy; in patients with coexisting mitral valve disease, surgical treatment is indicated.

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