Table 13.18-6. Summary of recommended regimens for LTBI treatment

Drug(s)

Duration

Schedule

Mode of administration

Level of evidence1

Standard regimen

INH

9 months

Daily

SAP

1

Acceptable alternative regimens

INH

6 months

Daily

SAP

1

INH/RMP

3 months

Daily

SAP

1

INH/RPT2

3 months

Once weekly

DOP

1

RMP

4 months

Daily

SAP

2

INH

6-9 months

Twice weekly

DOP

2

INH/RMP

3 months

Twice weekly

DOP

2

1 Level 1, multiple randomized trials. Level 2, single randomized trial and/or multiple observational (cohort) studies.

2 Use this regimen with careful monitoring for hypersensitivity reactions—these can be severe. RPT is only available in Canada through the Special Access Program.

Source: ©All Rights Reserved. Canadian Tuberculosis Standards, 7th Edition. The Public Health Agency of Canada, The Lung Association, and the Canadian Thoracic Society, 2014. Adapted and reproduced with permission from the Minister of Health, 2016.

DOP, directly observed prophylaxis; INH, isoniazid; LTBI, latent tuberculosis infection; RMP, rifampin (international nonproprietary name rifampicin); RPT, rifapentine; SAP, self-administered prophylaxis.