Table 7.4-3. Clinical and laboratory features which may assist in differentiating among DIC, TTP, HUS, and CAPS

Clinical features

DIC

TTP

HUS

CAPS

CNS manifestations

+/−

++

+/−

++

Renal impairment

+/−

+/−

+++

++

Liver impairment

+/−

+/−

+/−

+

Hypertension

−/+

+/−

Fever

+/−

+/−

−/+

−/+

Hemolysis

+

+++

++

+

Thrombocytopenia

+++

+++

++

++

Coagulopathy

+++

+/−

Adapted from Br J Haematol. 2003;120(4):556-73.

CAPS, catastrophic antiphospholipid syndrome; CNS, central nervous system; DIC, disseminated intravascular coagulation; HUS, hemolytic-uremic syndrome; TTP, thrombotic thrombocytopenic purpura.