1. Insidious onset

2. Clear-cut history of worsening

3. Initial and prominent cognitive deficits on history and examination with either amnestic or nonamnestic presentation

Variants

Language variant: progressive nonfluent aphasia

Visuospatial variant: posterior cortical atrophy

Frontal executive variant: frontal atrophy

AD is considered improbable in case of:

– Substantial evidence of cerebrovascular disease

– Core features of dementia with Lewy body present (complex visual hallucinations, early parkinsonism, fluctuating cognition)

– Prominent features of behavioral variant frontotemporal dementia (disinhibition, apathy, loss of empathy, hyperorality, executive dysfunction, perseverative behavior)

– Prominent features of semantic dementia or primary progressive aphasia

– Other neurologic or nonneurologic illness or drugs