Table 17.5-1. Selected aspects of management of patients with COPD and persistent dyspnea despite treatment

Current treatment

Recommended follow-up

LABA or LAMA

LABA + LAMA

LABA + LAMA

– Consider changing inhaler type or drug

– Look for alternative causes of dyspnea

– Consider switching back to bronchodilator monotherapy

– Consider LABA + LAMA + ICS

LABA + ICS

– LABA + LAMA + ICS

or

– LABA + LAMAa

LABA + LAMA + ICS

– Look for alternative causes of dyspnea

– LABA + LAMAa

a Consider in case of recent pneumonia, lack of indications for ICS, or lack of response to ICS treatment

COPD, chronic obstructive pulmonary disease; ICS, inhaled corticosteroid; LABA, long-acting beta2-agonist; LAMA, long-acting muscarinic antagonist.