|
Agent |
Dosage | |
|
Visceral leishmaniasis | ||
|
|
Liposomal amphotericin B |
3 mg/kg IV once daily for 5 days, then after 14 and 21 days from initiation of treatment until the total dose of 21 mg/kg is achieved |
|
Antimony(V) compounds (sodium stibogluconate, meglumine antimoniate) |
20 mg of antimony/kg IV or IM once daily for 28 days | |
|
Miltefosine |
2.5 mg/kg PO in 2-3 divided doses for 28 days | |
|
Cutaneous leishmaniasis | ||
|
|
Fluconazole |
200 mg PO once daily for 6 weeks |
|
Ketoconazole |
600 mg PO once daily for 4 weeks | |
|
Miltefosine |
2.5 mg/kg PO (up to 150 mg) in 3 divided doses for 28 days | |
|
Antimony(V) compounds (sodium stibogluconate, meglumine antimoniate) |
20 mg of antimony/kg IV or IM once daily for 10-20 days | |
|
Liposomal amphotericin B |
3 mg/kg IV once daily for 6-7 days | |
|
Pentamidine isethionate |
Drug of choice (4 mg of salt/kg IV or IM at an interval of 48 h) for cutaneous leishmaniasis caused by Leishmania (Viannia) guyanensis | |
|
IM, intramuscular; IV, intravenous; PO, orally. | ||