|
Drug |
Dosage |
|
First-line monotherapies | |
|
Lithium |
300-600 mg/d; final dosage depends on serum medication levels, clinical response, and age (see text) |
|
Quetiapine |
100 mg/d and increasing daily by 100 mg to a total of 600-800 mg/d |
|
Divalproex |
250-500 mg/d (target 1000-1500 mg/d) |
|
Asenapine |
5 mg bid (target 5-10 mg bid) |
|
Aripiprazole |
15 mg/d (target 15-30 mg/d) |
|
Paliperidone |
3 mg/d (target 6-12 mg/d) |
|
Risperidone |
2-3 mg/d (target 2-4 mg/d) |
|
Cariprazine |
Day 1: 1.5 mg/d; day 2+: 3 mg/d |
|
First-line combination therapies | |
|
Quetiapine + lithium/divalproex |
See above |
|
Aripiprazole + lithium/divalproex |
See above |
|
Risperidone + lithium/divalproex |
See above |
|
Asenapine + lithium/divalproex |
See above |