Risk category (10-year CVD risk)a

Serum target

Very high risk^b

LDL-C <70 mg/dL (<1.8 mmol/L); <55 mg/dL (<1.4 mmol/L) in some guidelines

High risk (FRS ≥20%)

LDL-C <2.0 mmol/L or reduce by >50%d

or

ApoB <0.8 g/L

or

Non–HDL-C <2.6 mmol/L

Intermediate risk (FRS 10%-19%) and ≥1 of:

1) LDL-C ≥3.5 mmol/L

2) Non–HDL-C ≥4.2 mmol/L

3) ApoB >1.05 g/L

4) Men >50 years, women >60 years (only with +1 additional CVD risk factor)c

Low risk (< 10%); consider treatment if LDL-C >5.0 mmol/L, or ApoB >1.45 g/L, or non-HDL of 5.8 mmol/L

>50% reduction in LDL-C

a See table 3.16-1.

b History of multiple major ASCVD events (recent ACS within the past 12 months, history of MI or ischemic stroke, symptomatic PAD) or 1 major ASCVD event and multiple high-risk conditions.

c Low HDL-C level, impaired fasting glucose, high waist circumference, active smoker, hypertension. Also high-sensitivity CRP ≥ 2.0 mmol/L, family history of premature CAD, high Lp(a) ≥ 50 mg/dL [≥100 nmol/L]n.

d LDL-C <1.8 mmol/L in patients with acute coronary syndrome in the last 3 months (<1.4 mmol/L in some guidelines).