Lupus nephritis class

Biopsy findings

Prevalence

I (minimal mesangial)

– Normal light microscopy

– Mesangial immune deposits on immunofluorescence

0%-1%

II (mesangial proliferative)

Mesangial hypercellularity or expansion

9.8%-18.1%

III (focal proliferative)

– Endocapillary or extracapillary glomerulonephritis involving <50% of glomeruli

– Subendothelial immune deposits

– Active or chronic

8.7%-10%

IV (diffuse proliferative)

– Endocapillary or extracapillary glomerulonephritis involving ≥50% of glomeruli

– Subendothelial deposits

– Active or chronic

– Segmental or global

36.9%-37.1%

V (membranous)

– Subepithelial deposits

– May occur with classes III or IV

11.7%-40.2%

VI (global glomerulosclerosis)

≥90% of globally sclerosed glomeruli

2.7%-4.3%