Table 6.2-2. Simplified diagnostic criteria for autoimmune hepatitis according to the International Autoimmune Hepatitis Group (2008)

Criteria

Score

Autoantibodies (max, 2 points)

 

 

ANA or SMA titer ≥1:40

1

ANA or SMA titer ≥1:80, anti-LKM1 titer ≥1:40, or positive anti-SLA/LP

2

IgG level

 

 

>ULN (16 g/L)

1

>1.1 × ULN (18 g/L)

2

Histology

 

 

Consistent with autoimmune hepatitis

1

Typical for autoimmune hepatitis

2

Viral hepatitis excluded

2

Interpretation:

Score 6: Probable autoimmune hepatitis

Score 7-8: Definite autoimmune hepatitis

Based on Hepatology. 2008;48(1):169-76.

ANA, antinuclear antibody; anti-LKM1, antibody to type 1 liver and kidney microsomal antigen; anti-SLA/LP, antibody to soluble liver antigen/liver-pancreas; SMA, smooth muscle antibody; ULN, upper limit of normal.