Table 14.3-8. Oral drugs for the management of hypertension in pregnancy

Drug

Starting dose

Maximum dose

Onset of action

Adverse effects

Special indications and notes

Labetalol

100 mg bid

500 mg qid

20‑40 min

Headache; avoid in uncontrolled asthma

Often requires tid or qid dosing in pregnancy; safe for breastfeeding

Nifedipine (slow release)

20 mg bid

60 mg bid

20‑40 min

Peripheral edema

Safe for breastfeeding

Methyldopa

250 mg bid

1 g qid

1‑3 h

Fatigue; avoid in uncontrolled depression

Safe for breastfeeding

bid, 2 times a day; qid, 4 times a day; tid, 3 times a day.