Table 8.10-1. Special platelet products

HLA-matched platelets

Poor response to platelet transfusion (platelet refractoriness) may occur in patients with antibodies to the HLA system. In such patients HLA-matched platelets may be of benefit to improve posttransfusion count increments.

HPA-matched platelets

 

Poor response to platelet transfusion (platelet refractoriness) may occur in patients with antibodies to the HPA system. In such patients HPA-matched platelets may be of benefit to improve posttransfusion count increments.

HPA-matched platelets may also be required in cases of posttransfusion purpura or neonatal alloimmune thrombocytopenia.

Washed platelets

May be considered in patients with confirmed IgA deficiency and anti-IgA antibodies in the presence of a history of severe allergic reactions. Washed platelets may also be indicated in patients who require platelet transfusions but have repeated allergic reactions unresponsive to other measures (eg, premedication).

Washed platelet concentrate contains platelets separated from plasma and suspended in solution.

Irradiated platelets

See Irradiation of Blood Products

HLA, human leukocyte antigen; HPA, human platelet antigen.