Table 7.2-3. Medical treatment for eosinophilic esophagitis

Treatment

Comments

Acid suppression

PPI:

– Dexlansoprazole

– Esomeprazole

– Lansoprazole

– Omeprazole

– Pantoprazole

– Rabeprazole

Standard-dose PPI:

– Once daily or bid

– 8-12 weeks

Glucocorticoids (topical)

Fluticasone propionate:

– Metered-dose inhaler

– Spray (swallowed)

Infants: 44 microg inhaler 2 puffs bid

Children: 110 microg inhaler 2 puffs bid

Adults: 220 microg inhaler 2 puffs bid

Budesonide:

– Nebulizer solution

– Swallowed as solution or in viscous sucralose slurry

Children: 0.25-0.5 mg bid

Adults: 1-2 mg bid

Dietary therapy

Elemental diet

– Amino acid–based formula (antigen-free)

– Oral intake: Poor adherence due to taste

6-food elimination diet

– Eliminate eggs, milk, nuts, seafood, soy, and wheat for 6 weeks

– If effective, reintroduce food groups individually every 6-8 weeks; repeat endoscopy and biopsy to evaluate response

4-food elimination diet

– Eliminate eggs, milk, soy, and wheat for 6 weeks

– If effective, reintroduce food groups individually every 6-8 weeks; repeat endoscopy and biopsy to evaluate response

2-food elimination diet

– Eliminate milk and wheat for 6 weeks

– If effective, reintroduce food groups individually every 6-8 weeks; repeat endoscopy and biopsy to evaluate response

bid, 2 times a day; PPI, proton pump inhibitor.