Table 10.8-5. Etiologies of nephrogenic diabetes insipidus

Inherited/hereditary

Vasopressin V2-receptor gene mutations (X-linked),a AQP2 gene mutations (autosomal dominant/autosomal recessive)

Acquired

– Systemic disorders: hypercalcemia,a amyloidosis, Sjögren syndrome, polycystic kidney disease, sickle cell disease

– Drugs: lithium,a cidofovir, foscarnet, amphotericin B

– Other: hypokalemia, pregnancy

a The most common causes.