Table 3.12-2. Selected lipid-lowering agents

Agent

Dosage

Statins

Atorvastatin

10-80 mg once daily

Fluvastatin

20-80 mg once daily

Lovastatin

20-80 mg once daily

Rosuvastatin

5-40 mg once daily

Simvastatin

5-80 mga once daily

Bile acid sequestrants (resins)

Cholestyramine

Start from 4 g once daily to bid, then titrate up to 4 g/d (max, 24 g/d in divided doses)

Colesevelam

1.875 g bid or 3.75 g once daily

Other

Ezetimibe

10 mg once daily

PCSK9 inhibitors

Evolocumab

140 mg SC every 2 weeks or 420 mg once monthly

Alirocumab

75 mg SC every other week, 150 mg SC every 2 weeks, or 300 mg every 4 weeks

a Note: The US Food and Drug Administration does not recommend the use of simvastatin at a dose of 80 mg/d because of increased incidence of myopathy.

PCSK9, proprotein convertase subtilisin/kexin type 9; SC, subcutaneous.