|
Agent |
Dosage |
|
Statins | |
|
Atorvastatin |
10-80 mg once daily |
|
Fluvastatin |
20-80 mg once daily |
|
Lovastatin |
20-80 mg once daily |
|
Rosuvastatin |
5-40 mg once daily |
|
Simvastatin |
5-80 mga once daily |
|
Pitavastatin (not used in Canada) |
1-4 mg once daily |
|
Bile acid sequestrants (resins) | |
|
Cholestyramine |
Start from 4 g once daily to bid, then titrate up to 4 g/d (max, 24 g/d in divided doses) |
|
Colesevelam |
1.875 g bid or 3.75 g once daily |
|
Other | |
|
Ezetimibe |
10 mg once daily |
|
PCSK9 inhibitors | |
|
Evolocumab |
140 mg SC every 2 weeks or 420 mg once monthly |
|
Alirocumab |
75 mg SC every other week, 150 mg SC every 2 weeks, or 300 mg every 4 weeks |
|
a Note: The US Food and Drug Administration does not recommend the use of simvastatin at a dose of 80 mg/d because of increased incidence of myopathy. | |
|
PCSK9, proprotein convertase subtilisin/kexin type 9; SC, subcutaneous. | |