|
Drug |
Common daily dose (mg)a |
Common starting dose (mg)b |
First daily target dose (mg)c |
p450d |
Comments |
|
Carbamazepine |
600-1200 |
100-200 |
600-900 |
Inducer |
Self-induction at p450 |
|
Lamotrigine |
100-300 |
25 |
100 |
– |
Slow titration mandatory |
|
Levetiracetam |
1000-3000 |
250-500 |
1000-1500 |
– |
Excreted by kidneys |
|
Cenobamate |
100-400 |
12.5 |
100-150 |
Inhibition of CYP2C19 Induction of CYP3A4 |
New drug |
|
Lacosamide |
100-400 |
50-100 |
150-200 |
– |
Excreted by kidneys |
|
Oxcarbazepine |
600-1800 |
300 |
900-1200 |
Inducer |
Prodrug; converted to 10-OH-CBZ |
|
Perampanel |
6-12 |
2 |
4-6 |
– |
Very long half-life |
|
Topiramate |
50-200 |
25-50 |
100-150 |
Inducer |
Hepatic enzyme induction >200 mg |
|
Valproic acid |
900-2000 |
300-500 |
900-1200 |
Inhibitor |
Caution when adding to lamotrigine |
|
Zonisamide |
100-400 |
50 |
100-200 |
– |
Long half-life |
|
a The common daily dose refers to average levels. The upper value does not represent the maximum dose. b The common starting dose refers to usual starting doses per day. c The first daily target dose is a suggestion and refers to doses to be targeted by slow titration. d Agents with significant impact on drug metabolism by the liver. |
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