|
Agent |
Half-life (h) |
Daily dose (mg) |
|
Bromocriptine |
6a |
7.5-30 |
|
Pergolide |
12-27 |
1.5-12 |
|
Cabergoline |
65 |
2-5 |
|
Pramipexoleb |
8-12 |
1.5-4.5c |
|
Ropiniroleb |
4-6 |
9-24 |
|
Piribedil |
2-7 |
100-250 |
|
Rotigotined |
5-7 |
2-16 |
|
Apomorphine |
0.55 |
Rescue treatment, per dose: 10-30/2-6e Infusion: 4-7/h |
|
a Complex pharmacokinetics. The half-life in the initial phase of elimination is several hours and subsequently extends to 45-50 hours. b Extended-release agents are available, for once-daily administration. c Dose for pramipexole dihydrochloride. d Transdermal patch intended to be worn for 24 hours and then replaced. e Rescue treatment: sublingual film/subcutaneous injection. | ||