Table 17.11-2. TNM staging and treatment methods for non–small cell lung carcinoma

Stage

T

N

M

 

Latent

x

0

0

 

Stage 0

is

0

0

 

Stage IA1

1(mi)

0

0

Surgery with or without adjuvant therapy, radiation therapy

1a

0

0

Stage IA2

1b

0

0

Stage IA3

1c

0

0

Stage IB

2a

0

0

Stage IIA

2b

0

0

Surgery with or without adjuvant and/or neoadjuvant therapy, radiation therapy

Stage IIB

1a, 1b, 1c

1

0

2a

1

0

2b

1

0

3

0

0

Stage IIIA

1a, 1b, 1c

2

0

Resected or resectable disease: Surgery with or without adjuvant and/or neoadjuvant therapy, immunotherapy, chemoradiation

Unresectable disease: Chemoradiation, radiation therapy, targeted therapy, immunotherapy

Superior sulcus tumors: Surgery, chemoradiation followed by surgery, radiation therapy alone

Tumors that invade the chest wall: Surgery, surgery and radiation therapy, radiation therapy alone, chemotherapy combined with radiation therapy and/or surgery

 

2a, 2b

2

0

3

1

0

4

0, 1

0

Stage IIIB

1a, 1b, 1c

3

0

Sequential or concurrent chemotherapy and radiation therapy, radiation therapy alone, targeted therapy, immunotherapy

2a, 2b

3

0

3

2

0

4

2

0

Stage IIIC

3

3

0

Sequential or concurrent chemotherapy and radiation therapy, radiation therapy alone, targeted therapy, immunotherapy

4

3

0

Stage IVA

Any

Any

1a, 1b

Chemotherapy, targeted therapy, immunotherapy, radiation therapy (for palliation) or symptomatic treatment

Stage IVB

Any

Any

1c

Based on Amin MB, Edge S, Greene F, et al, eds. AJCC Cancer Staging Manual (8th edition). Springer International Publishing: American Joint Commission on Cancer; 2017.

Updated from the National Cancer Institute. Non-Small Cell Lung Cancer Treatment (PDQ®)–Health Professional Version. Updated August 30, 2024.

TNM, tumor, node, metastasis.