Drugs

Dosage

Specific indications

Contraindications

Sacubitril/valsartan

24/26-97/103 mg bid

Congestive heart failure

As in ARBs (see table 3.9-3)

Doxazosin

1-16 mg once daily

Prostatic hypertrophy

Orthostatic hypotension, heart failure

Terazosin

1-20 mg once daily

Methyldopa

0.25-1 g bid

Hypertension in pregnancy; use in combination with a diuretic

Liver failure, pheochromocytoma, hemolytic anemia, depression, sexual dysfunction

Clonidine

0.05-0.2 mg bid to tid

Use in combination with a diuretic

Renal or liver failure, depression, sick sinus syndrome, bradyarrhythmia

Moxonidinea

0.2-0.6 mg/d

Mild and moderate hypertension, especially in young patients with symptoms of sympathetic activation

Severe depression, severe renal failure

Rilmenidinea

1 mg once daily to bid

Hydralazine

75-200 mg/d in 3-4 divided doses

Use in exceptional cases in combination with a diuretic and a beta-blocker

Tachycardia, cerebrovascular disease, mitral stenosis, aortic aneurysm, hypertrophic cardiomyopathy, ischemic heart disease, liver and kidney dysfunction, porphyria

a Not available in Canada.