Adverse events of first-line and second-line drugs - McMaster Textbook of Internal Medicine

Table 17.22-2. Adverse events of first-line and second-line drugs
	Common adverse events	Uncommon but important adverse events	Rank for probability of hepatitisa	Rank for probability of rash
First-line drugs
Isoniazid	Rash, hepatitis, neuropathy	CNS toxicity, anemia	2	3
Rifampin	Drug interactions, rash	Hepatitis, influenza-like illness, neutropenia, thrombocytopenia	3	1
Pyrazinamide	Hepatitis, rash, arthralgia	Gout	1	2
Ethambutol	Eye toxicity	Rash	4	4
Second-line drugs
Fluoroquinolones	Rash	Tendonitis, tendon rupture, QT interval prolongation
Amikacin	Nephrotoxicity, ototoxicity
a 1, most likely; 4, least likely.
Source: ©All Rights Reserved. Canadian Tuberculosis Standards, 7th Edition. The Public Health Agency of Canada, The Lung Association, and the Canadian Thoracic Society, 2014. Adapted and reproduced with permission from the Minister of Health, 2016.
CNS, central nervous system.