Table 13.18-4. Adverse events of first-line and second-line drugs

Common adverse events

Uncommon but important adverse events

Rank for probability of hepatitis1

Rank for probability of rash

First-line drugs

Isoniazid

Rash, hepatitis, neuropathy

CNS toxicity, anemia

2 3

Rifampin (INN rifampicin)

Drug interactions, rash

Hepatitis, influenza-like illness, neutropenia, thrombocytopenia

3 1

Pyrazinamide

Hepatitis, rash, arthralgia

Gout

1 2

Ethambutol

Eye toxicity

Rash

4 4

Second-line drugs

Fluoroquinolones

Rash

Tendonitis, tendon rupture, QT interval prolongation

Amikacin

Nephrotoxicity, ototoxicity

1 1, most likely; 4, least likely.

Source: ©All Rights Reserved. Canadian Tuberculosis Standards, 7th Edition. The Public Health Agency of Canada, The Lung Association, and the Canadian Thoracic Society, 2014. Adapted and reproduced with permission from the Minister of Health, 2016.

CNS, central nervous system; INN, international nonproprietary name.