|
Characteristic features |
EoE |
GERD | |
|
Coexisting atopic diseases |
Common |
As in general population | |
|
Food hypersensitivity |
Common |
As in general population | |
|
Sex |
M > F |
M = F | |
|
Dysphagia (particularly with allergenic foods) |
Common |
Uncommon | |
|
pH-metry |
Normal in most |
Abnormal | |
|
Endoscopy |
Frequent lesions, characteristic appearance |
Normal in 40%-60% | |
|
Histology | |||
|
Distal esophagus Proximal esophagus |
Lesions present Lesions present |
Lesions present Normal findings | |
|
Epithelial hyperplasia |
Significant |
Mild | |
|
Mucosal eosinophilia |
>15 per HPF |
0-7 per HPF | |
|
Treatment | |||
|
H2 blockers |
Useful in some |
Useful in some | |
|
PPIs |
Useful in some |
Useful | |
|
Glucocorticoids |
Useful |
No effect | |
|
Elimination diet |
Useful |
No effect | |
|
EoE, eosinophilic esophagitis; F, female; GERD, gastroesophageal reflux disease; HPF, high-power field; M, male; PPI, proton pump inhibitor. | |||