Indication

Agent

Dosage

Severe malaria (most frequently caused by P falciparum); use parenteral treatment for ≥24 h, until oral administration is possible, then start ACT

Artesunate (first-line agent)

2.4 mg/kg IV or IM in 3 doses over 24 h: at 0, 12, and 24 h; then switch to once daily

Artemether

IM, starting dose of 3.2 mg/kg; followed by 1.6 mg/kg once daily

Quinine (salt)

20 mg/kg in IV infusion followed by 10 mg/kg every 8 h

Uncomplicated malaria caused by P falciparum (ACTs)

Artemether + lumefantrine

Body weight ≥35 kg: 80 mg + 480 mg PO bid for 3 days; the first 2 doses should be administered at an 8-h interval

Artesunate + amodiaquine

Body weight ≥36 kg: 200 mg + 540 mg PO once daily for 3 days

Artesunate + mefloquine

Body weight ≥30 kg: 200 mg + 440 mg PO once daily for 3 days

Dihydroartemisinin + piperaquine

Body weight ≥36 kg and <60 kg: 120 mg + 960 mg PO once daily for 3 days; body weight ≥60 kg and <80 kg: 160 mg + 1280 mg PO once daily for 3 days; in persons with body weight ≥80 kg: 200 mg + 1600 mg PO once daily for 3 days

Artesunate + SP

Body weight ≥50 kg: 200 mg of artesunate PO for 3 days + 1500 mg/75 mg SP PO in a single dose on day 1

Artesunate + pyronaridine

Body weight ≥45 kg and <65 kg: 180 mg + 540 mg PO once daily for 3 days; body weight ≥65 kg: 240 mg + 720 mg PO once daily for 3 days

Reduction of P falciparum malaria transmission following treatment in endemic regions with low transmission rates

Primaquine

0.25 mg/kg PO, in a single dose

Uncomplicated malaria in travelers returning from the tropics

ACT

As above

Atovaquone + proguanil

1000 mg + 400 mg PO once daily for 3 days

Uncomplicated malaria caused by other Plasmodium species

ACT

As above

Chloroquine

10 mg/kg PO once daily for 2 days, 5 mg/kg on day 3

Uncomplicated malaria in the first trimester of pregnancy

Quinine (salt) + clindamycin

650 mg PO tid + 10 mg/kg PO bid for 7 days

P vivax and P ovale relapse prevention after acute infection treatment

Primaquine

0.25-0.5 mg/kg PO once daily for 14 days