Disease

Occurrence (%)

Graft loss (%)

aHUSa

15-100

~50

Amyloidosis

20-40

N/A

ANCA-associated vasculitis

~17

<10

Anti-GBM disease

20-30

<10

C3 glomerulopathya

60-80

35-50

Fibrillary glomerulopathy

~50

N/A

FSGS

20-50

10-40

IgA nephropathy

30-60

15-30

IgA vasculitis (formerly Henoch-Schönlein purpura)

~50

10-20

Light chain deposition disease

~50

N/A

Lupus nephropathy

1

Rarely

Membranous nephropathy

20-30

~30

Mixed idiopathic cryoglobulinemia

~70

N/A

Systemic scleroderma

~20

N/A

Waldenström macroglobulinemia

10-25

N/A

a Depending on the mutation of genes encoding proteins regulating the activity of the alternative complement pathway and type of prophylaxis used.