Table 15.4-4. Drugs for the treatment of nausea and/or vomiting in pregnancy

Drug

Dose

Adverse effects

Diclectina

2 tablets at bedtime (max 8 tablets/d)

Drowsiness

Antihistamines

Dimenhydrinate

 25-50 mg PO/PR/IV every 4-6 h

Drowsiness

Dopamine antagonists

Metoclopramide

5-10 mg PO/IM/IV every 8 h

Drowsiness, fatigue, change in bowel habits, extrapyramidal effects (eg, dystonia, tardive dyskinesia)

Phenothiazines

Chlorpromazine

12.5-50 mg PO/PR/IM/IV every 6-8 h

Drowsiness

Prochlorperazine

5-10 mg PO/PR/IM/IV every 6-8 h

Serotonin 5-HT3 inhibitors

Ondansetron

4-8 mg PO/IV every 8 h

Constipation, QT prolongation

a Doxylamine 10 mg/pyridoxine 10 mg.

IM, intramuscular; IV, intravenous; PO, oral; PR, per rectum.