Differential diagnosis and treatment of latent autoimmune diabetes in adults and type 2 diabetes mellitus

Table 6.2-1. Differential diagnosis and treatment of LADA and type 2 diabetes mellitus
Differential features	LADA	Type 2 diabetes mellitus
Body mass index	As in general population	Obesity or overweight
Hypertension	No	Yes
Family history of diabetes	No	Yes
History/family history of autoimmune diseases	Yes	No
Anti-GAD or other islet cell antibodies	Yes	No
C-peptide (glucagon test)	Low level	Normal or initially increased
Treatment of choice	Insulin	Initial treatment with oral antidiabetic agents
GAD, glutamic acid decarboxylase; LADA, latent autoimmune diabetes in adults.