Table 6.2-1. Differential diagnosis and treatment of latent autoimmune diabetes in adults and type 2 diabetes mellitus

Differential features

LADA

Type 2 diabetes mellitus

Body mass index

As in general population

Obese or overweight

Hypertension

No

Yes

Family history of diabetes

No

Yes

Past or family history of autoimmune diseases

Yes

No

Anti-GAD or other islet cell antibodies

Yes

No

C-peptide (glucagon test)

Low level

Normal or initially increased

Treatment of choice

Insulin

Initial treatment with oral antidiabetic agents

GAD, glutamic acid decarboxylase; LADA, latent autoimmune diabetes in adults.