Table 6.2-2. Differential diagnosis and treatment of maturity-onset diabetes of youth (MODY) and type 1 diabetes mellitus

Differential features

MODY

Type 1 diabetes mellitus

Congenital malformations (most frequently affecting the kidneys and urogenital system)

Possible

No

≥3 generations of family history of diabetes mellitus

Yes

No

Past or family history of autoimmune diseases

No

Yes

Islet cell antibodies

No

Yes

C-peptide (glucagon test)

Initially normal

Low level

Treatment of choice

Initial treatment with oral antidiabetic agents

Insulin

Onset

Slow

Usually acute