Differential diagnosis and treatment of maturity-onset diabetes of youth (MODY) and type 1 diabetes mellitus

Table 6.2-2. Differential diagnosis and treatment of MODY and type 1 diabetes mellitus
Differential features	MODY	Type 1 diabetes mellitus
Congenital malformations (most frequently affecting the kidneys and urogenital system)	Possible	No
≥3 generations of family history of diabetes mellitus at age <30 years	Yes	No
History/family history of autoimmune diseases	No	Yes
Islet cell antibodies	No	Yes
C-peptide level	Initially normal	Low
Treatment of choice	Initial treatment with sulfonylureas	Insulin
Onset	Slow and often asymptomatic	Usually acute
MODY, maturity-onset diabetes of youth.