Table 6.2-3. Insulin pharmacokinetics (effective duration may differ markedly)

Insulin preparations

Time of action

Onset

Peak

Effective duration

Rapid-acting insulin analogues

Aspart

5-20 min

40-75 min

3-5 h

Glulisine

5-20 min

40-75 min

3-5 h

Lispro

5-20 min

40-75 min

3-5 h

Short-acting insulins

Regular

30 min

2-4 h

5-8 h

Intermediate-acting insulins

NPH (isophane)

2 h

4-12 h

10-18 h

Long-acting insulin analogues

Detemir

2 h

3-9 h

8-24 h

Glargine

2 h

No peak

20 to >24 h

Degludec

2 h

No peak

>40 h

NPH, neutral protamine Hagedorn.