Table 8.8-1. Rai classification of chronic lymphocytic leukemia

 

Stage

0

I

II

III

IV

Lymphocytosis

+

+

+

+

+

Lymphadenopathy

+

+/–

+/–

+/–

Splenomegaly or hepatomegaly

+

+/–

+/–

Anemia (hemoglobin <11 g/dL)

+

+/–

Thrombocytopenia (<100,000/microL)

+

Percentage of patientsa

30

25

25

10

10

Median survival (years)

12.5

8.4

6

1.5

 

a At the moment of diagnosis.

Based on Blood. 1975;46(2):219-34 and Ann Oncol. 2005;16 Suppl 1:i50-1.