Table 9.3-1. Dosage of factor VIII and factor IX in the treatment of moderate to severe hemophilia

Indication

Hemophilia A, dose of factor VIII concentrate (IU/kg)

Hemophilia B, dose of factor IX concentrate (IU/kg)

Treatment duration (days)a

Bleeding to joints and/or muscles, epistaxis, gingival bleeding

20-30

40-60

1-2 days; in case of unsatisfactory effects increase dose and prolong treatment

Tooth extractionb

25

40

Once before procedure

Bleeding: to lower wall of oral cavity and to neck; gastrointestinal; to iliopsoas; intracranial; retroperitoneal hematomas; surgical procedures

40-50

60-80

For 1-7 days after onset of bleeding, then reduce dose

a Depending on the clinical situation, administer a factor VIII concentrate every 8, 12, or 24 hours (hemophilia A) and factor IX concentrate every 12, 18, or 24 hours (hemophilia B).

b For 7 days from the extraction, administer tranexamic acid 10-15 mg/kg every 8 hours.