Dosage of factor VIII and factor IX in the treatment of moderate to severe hemophilia

Table 9.2-1. Dosage of factor VIII and factor IX in the treatment of moderate to severe hemophilia
Indication	Hemophilia A, dose of factor VIII concentrate (IU/kg)	Hemophilia B, dose of factor IX concentrate (IU/kg)	Treatment duration (days)a
Bleeding to joints and/or muscles, epistaxis, gingival bleeding	20-30	40-60	1-2 days; in case of unsatisfactory effects increase dose and prolong treatment
Tooth extractionb	25	40	Once before procedure
Bleeding: to lower wall of oral cavity and to neck; gastrointestinal; to iliopsoas; intracranial; retroperitoneal hematomas; surgical procedures	40-50	60-80	For 1-7 days after onset of bleeding, then reduce dose
a Depending on the clinical situation, administer a factor VIII concentrate every 8, 12, or 24 hours (hemophilia A) and factor IX concentrate every 12, 18, or 24 hours (hemophilia B). b For 7 days from the extraction, administer tranexamic acid 10-15 mg/kg every 8 hours.