Features differentiating systemic connective tissue diseases - McMaster Textbook of Internal Medicine

Table 18.12-3. Features differentiating systemic connective tissue diseases
Clinical symptom		SLE	RA	SSc	PM	MCTD
Pleuritis or pericarditis		++++	+	+	–	+++
Arthritis with joint destruction		±	++++	+	±	+
Raynaud phenomenon		++	–	++++	+	++++
Myositis		+	+	+	++++	+++
Sclerodactyly		±	–	++++	–	++
Skin thickening		–	–	+++	–	–
Interstitial lung disease		+	+	+++	++	+
Pulmonary hypertension		+	±	++	+	+++
Butterfly rash		++++	–	–	–	++
Oral ulcers		+++	–	–	–	++
Seizures or psychosis		+++	–	–	–	–
Nerve V neuropathy		+	–	++	–	+++
Peripheral polyneuropathy		++	++	±	–	++
Transverse myelitis		+++	+	–	–	++
Aseptic meningitis		+++	+	–	–	+++
Glomerulonephritis
	Proliferative	++++	–	–	–	+
	Membranous	+++	–	–	–	++
Renovascular hypertension		+	–	++++	–	+++
Cutaneous (leukocytoclastic vasculitis on skin biopsy) or systemic vasculitis, including renal, neurologic, and pulmonary manifestations)		++	++	+	+	+
Noninflammatory vasculopathy		–	–	++++	–	+++
Impaired esophageal motility		±	±	++++	++	+++
Anti-RNP		++	–	+	+	++++
Anti-Sm		+++	–	–	–	–
Anti-dsDNA		++++	–	–	–	–
Anti-Scl-70, ACAs, anti-RNA polymerase III		–	–	+++	–	–
↓ levels of complement components		+++	–	–	–	+/–
Rheumatoid factor		++	+++	+	+	++
The number of pluses denotes the frequency.
↓, decreased; ACA, anticentromere antibody; dsDNA, double-stranded DNA; MCTD, mixed connective tissue disease; PM, polymyositis; RA, rheumatoid arthritis; RNP, ribonucleoprotein; SLE, systemic lupus erythematosus; SSc, systemic sclerosis.