|
Agent |
Starting dose (mg/d) |
Usual dose (mg/d) |
|
Loop diuretics | ||
|
Furosemidea |
20-40 |
40-240 |
|
Torasemide |
5-10 |
10-20 |
|
Thiazide and thiazide-like diuretics | ||
|
Chlorthalidone |
12.5-25 |
25-100 |
|
Hydrochlorothiazide |
25 |
12.5-100 |
|
Indapamide |
2.5 (1.5 mg when using controlled-release formulations) |
2.5-5 |
|
Potassium-sparing diureticsb | ||
|
Amiloride (available only in a fixed combination with hydrochlorothiazide) |
2.5 (5) |
5-10 (10-20) |
|
Eplerenone |
25 (50) |
50 (100) |
|
Spironolactone |
12.5-25 (50) |
50 (100-200) |
|
a The diuretic effect starts within 30-60 min, peaks in 1-2 h, and ends after 6-8 h. b Doses used in patients who are not treated with an angiotensin-converting enzyme inhibitor or an angiotensin receptor blocker are given in parenthesis. | ||