Table 3.8-2. Dosage of evidence-informed beta-blockers in patients with chronic heart failure

Beta-blocker

Starting dose (mg)a

Subsequent doses up to target dose (mg)

Bisoprolol

1.25

2.5 to 3.75 to 5 to 7.5 to 10

Carvedilol

3.125

6.25 to 12.5 to 25 to 50

Metoprolol succinate controlled-release

12.5 or 25

25 to 50 to 100 to 200

a Carvedilol is administered 2 times a day, while other listed beta-blockers are administered once daily. The table lists single doses of the agents.