Table 3.9-5. Typical dosage of oral antihypertensive agents

Agents and formulations

Dosage

Beta-blockers

Acebutolol

400 mg once daily or 200 mg bid

Atenolol

25-100 mg once daily

Betaxolol

5-20 mg once daily

Bisoprolol

2.5-10 mg once daily (max, 20 mg/d)

Celiprolola

100-400 mg once daily

Carvedilol

6.25-25 mg once daily or bid

Metoprolol
 

Standard release

Controlled release

25-100 mg bid

50-100 mg once daily (up to 200 mg once daily)

Nebivolol

5 mg once daily

Pindolol

5-10 mg/d bid (doses up to 20 mg/d may be administered once daily; max, 60 mg/d)

Propranolol

40-80 mg bid to qid

Calcium channel blockers (CCBs)

Amlodipine

2.5-10 mg once daily

Diltiazem
 

Standard release

Controlled release

30-60 mg tid

90-480 mg once daily or 90-240 mg bid

Felodipine

5-10 mg once daily

Isradipinea

2.5-10 mg once daily or 5 mg bid

Lacidipinea

4-6 mg once daily

Lercanidipinea

10-20 mg once daily

Nitrendipinea

10-20 mg once daily (max, 20 mg bid)

Verapamil
 

Standard release

Extended release

40-120 mg tid to qid

120-240 mg once daily to bid

Diuretics    

Amiloride in a fixed-dose combination with hydrochlorothiazide

2.5-5 mg once daily to bid

Chlorthalidone

12.5-50 mg once daily or 50 mg every other day

Furosemide

20-40 mg daily to bid (typically bid when used as an antihypertensive)

Hydrochlorothiazide

12.5-50 mg once daily

Indapamide
 

Standard release

Extended release

1.25-2.5 mg once daily

1.5 mg once daily

Clopamidea

5-20 mg once daily

Spironolactone

25-50 mg once daily to bid

Torasemidea

2.5-10 mg once daily

Angiotensin-converting enzyme inhibitors (ACEIs)

Benazepril

5-20 mg once daily to bid

Quinapril

5-40 mg once daily to bid

Cilazapril

2.5-5 mg once daily

Enalapril

2.5-20 mg once daily to bid (bid preferred)

Imidaprila

5-20 mg once daily

Captopril

25-50 mg bid to tid

Fosinopril

10-40 mg daily

Lisinopril

10-40 mg once daily

Perindopril

4(5)-8(10) mg once daily

Ramipril

2.5-5 mg once daily (max, 10 mg)

Trandolapril

2-4 mg once daily

Zofenoprila

30 mg once daily (up to 60 mg once daily or in 2 divided doses)

Angiotensin receptor blockers (ARBs)

Eprosartan

600 mg once daily

Irbesartan

150-300 mg once daily

Candesartan

8-32 mg once daily

Losartan

25-100 mg once daily or in 2 divided doses

Telmisartan

20-80 mg once daily

Valsartan

80-320 mg once daily

a Not available in Canada.

bid, 2 times a day; qid, 4 times a day; tid, 3 times a day.