|
aPTT (s)a |
IV bolus |
Continuous IV infusion |
|
First dose |
80 IU/kg |
18 IU/kg/h |
|
<35 (<1.2 × control) |
80 IU/kg |
Increase by 4 IU/kg/h |
|
35-45 (1.2-1.5 × control) |
40 IU/kg |
Increase by 2 IU/kg/h |
|
46-70 (1.5-2.5 × control)b |
Without IV injection |
No change |
|
71-90 (2.5-3 × control) |
Without IV injection |
Reduce by 2 IU/kg/h |
|
>90 (>3 × control) |
Without IV injection |
Stop the infusion for 1 h, then reduce by 3 IU/kg/h |
|
a Sample numerical values expressed in seconds may vary depending on the reference (control) values in a given laboratory. b The therapeutic aPTT range of 46-70 s should correspond to the anti-Xa activity of 0.3-0.7 IU/mL. Note: Repeat aPTT and adjust the unfractionated heparin dose after 6 hours. | ||
|
aPTT, activated partial thromboplastin time; IV, intravenous. | ||