Table 3.11-11. Definitions of risk of cardiovascular events in various diagnostic studies

Study

Risk

High

Intermediate

Low

ECG stress testa

Annual cardiovascular mortality

>3%

1%-3%

<1%

Imaging studies

Area of ischemia

>10%b

1%-10%c

Coronary CTA

Coronary lesions

Significant stenosisd

Significant stenosise

Normal coronary arteries or atherosclerotic plaques only

a Risk assessment using the Duke treadmill score including exercise workload in time expressed in metabolic equivalents, ST-T changes during and after exercise, and clinical symptoms (no angina, angina, or angina causing discontinuation of the test). Calculator available at www.cardiology.org/tools/medcalc/duke.

b >10% in SPECT; the quantitative data for MRI are limited: probably ≥2 segments (out of 16) with new areas of hypoperfusion; ≥3 segments (out of 17) with dysfunction caused by dobutamine; or ≥3 segments (out of 17) with abnormal wall motion observed on stress echocardiography.

c Or any ischemia rated as lower than high-risk on MRI of the heart or stress echocardiography.

d That is, 3-vessel disease with proximal stenosis of the large coronary arteries, stenosis of the left main coronary artery, or proximal stenosis of the LAD.

e Non–high-risk stenosis of proximal large coronary arteries.

Adapted from Eur Heart J. 2013;34(38):2949-3003.

CTA, computed tomography angiography; ECG, electrocardiography; LAD, left anterior descending artery; MRI, magnetic resonance imaging; SPECT, single-photon emission computed tomography.