Agent and dosage

Indications

ASA 70-100 mg/d

Lifelong in all patients unless contraindicated

Clopidogrel 75 mg once daily

or

Ticagrelor 90 mg bid

or

Prasugrel 10 mg once daily

– Lifelong in patients with ASA contraindications or intolerance

– Combined with ASA for 12 months after ACS

– Combined with ASA for 12 months after ACS

 – Combined with ASA for 12 months after ACS

Beta-blocker

– All patients after UA/NSTEMI with LV dysfunction unless contraindicated

– All patients after STEMI unless contraindicated

ACEI

– Patients after UA/NSTEMI with heart failure, LV dysfunction (LVEF <40%), hypertension, diabetes mellitus, or chronic kidney disease. Consider in all other patients as prevention of further ischemic events

– All patients after STEMI

Statin

All patients (unless contraindicated) regardless of baseline cholesterol levels. Target LDL-C <1.8 mmol/L or 70 mg/dL (<1.4 mmol/L [55 mg/dL] according to ESC guidelines)

ARB

All patients who do not tolerate ACEI, and particularly those with heart failure and LV dysfunction (LVEF <40%)

MRA

Patients after MI treated with beta-blockers and ACEI with LVEF <40% and with diabetes mellitus or heart failure but without significant renal dysfunction or hyperkalemia