Table 6.3-2. Signs and symptoms of anterior pituitary insufficiency according to deficiencies of individual pituitary hormones


Signs and symptoms


Growth retardation (in children), decreased muscle mass, increased body fat (primarily visceral fat), decreased bone mineral density, hypoglycemia, hyperlipidemia (in adult-onset deficiency, signs and symptoms are nonspecific)


Orthostatic hypotension, syncope, nausea and vomiting, anorexia, weight loss, elevated body temperature, decreased skin pigmentation, tendency to hypoglycemia (particularly in patients with coexisting GH deficiency)


Secondary hypothyroidism (signs and symptoms are less pronounced than in primary hypothyroidism, goiter is absent)

LH and FSH

Amenorrhea, male sexual dysfunction, decreased libido, disappearance or lack of tertiary sexual characteristics (pubic hair)


No lactation after childbirth

ACTH, adrenocorticotropic hormone; FSH, follicle-stimulating hormone; GH, growth hormone; LH, luteinizing hormone; PRL, prolactin; TSH, thyroid-stimulating hormone.