Table 6.3-2. Signs and symptoms of anterior pituitary insufficiency according to deficiencies of individual pituitary hormones

Deficiency

Signs and symptoms

GH

Growth retardation (in children), decreased muscle mass, increased body fat (primarily visceral fat), decreased bone mineral density, hypoglycemia, hyperlipidemia (in adult-onset deficiency, signs and symptoms are nonspecific)

ACTH

Orthostatic hypotension, syncope, nausea and vomiting, anorexia, weight loss, elevated body temperature, decreased skin pigmentation, tendency to hypoglycemia (particularly in patients with coexisting GH deficiency)

TSH

Secondary hypothyroidism (signs and symptoms are less pronounced than in primary hypothyroidism, goiter is absent)

LH and FSH

Amenorrhea, male sexual dysfunction, decreased libido, disappearance or lack of tertiary sexual characteristics (pubic hair)

PRL

No lactation after childbirth

ACTH, adrenocorticotropic hormone; FSH, follicle-stimulating hormone; GH, growth hormone; LH, luteinizing hormone; PRL, prolactin; TSH, thyroid-stimulating hormone.