Cardiac-Specific Troponins I and T (cTnI, cTnT)

How to Cite This Chapter: Don-Wauchope A, Chetty VT, Ivica J, Kavsak P, Khan WI, Lafreniere M, Nouri K, Solnica B. Cardiac-specific Troponins I and T (cTnI, cTnT). McMaster Textbook of Internal Medicine. Kraków: Medycyna Praktyczna. Accessed June 22, 2024.
Last Updated: May 9, 2022
Last Reviewed: May 9, 2022
Chapter Information

For a brief introduction and guide to abbreviations, see Laboratory Tests: General Remarks.

Analyte [material]

Cardiac-specific troponins I and T (cTnI, cTnT) [S/P]

Reference range, target level, or decision threshold

cTnI: 9-80 ng/L (depending on method)!!!

cTnT: 9-22 ng/L (value diagnostic of significant myocardial damage)!!!

High-sensitivity cTnI and high-sensitivity cTnT assays are reported in ng/L and have sex-specific and pediatric-specific upper reference limits.

Interpretation of results

↑ Myocardial damage: MI, myocardial injury (mechanical, due to cardiac surgery, resuscitation, cardioversion/defibrillation), heart failure, hypertrophic cardiomyopathy, aortic dissection, aortic valve disease, PE, tachyarrhythmias, rhabdomyolysis with cardiac involvement, renal failure, stroke, subarachnoid hemorrhage, myocardial infiltrates (amyloidosis, hemochromatosis, sarcoidosis), sepsis, respiratory failure, burns, cardiotoxic drugs

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