Uric Acid

Analyte [material]

Uric acid [S/P/U24h]

Reference range, target level, or decision threshold

180-420 micromol/L (3-7 mg/dL)CW

Men: <4.8 mmol/24 h (800 mg)

Women: <4.5 mmol/24 h (750 mg)

Interpretation of results

↑ Primary gout, increased dietary purine-rich food consumption, acute or chronic renal failure, metabolic syndrome, diuretic therapy, hypothyroidism, carbon monoxide or lead poisoning, malignancies, tissue degradation (eg, tumor lysis syndrome after chemotherapy)

↓ Xanthine inhibitor therapy (allopurinol, febuxostat), congenital xanthine oxidase deficiency, pregnancy, syndrome of inappropriate antidiuretic hormone secretion, acromegaly, tubulopathies, uricosuric drugs (salicylates, phenylbutazone, probenecid, glucocorticoids)