Complement, Total (CH50), C3, and C4

How to Cite This Chapter: Don-Wauchope A, Chetty VT, Ivica J, Kavsak P, Khan WI, Lafreniere M, Nouri K, Solnica B. Complement, Total (CH50), C3, and C4. McMaster Textbook of Internal Medicine. Kraków: Medycyna Praktyczna. https://empendium.com/mcmtextbook/chapter/B31.1269.3.7.184. Accessed December 23, 2024.

Last Updated: May 9, 2022

Last Reviewed: May 9, 2022

Chapter Information

For a brief introduction and guide to abbreviations, see Laboratory Tests: General Remarks.

Analyte [material]

Complement, total (CH50), C3, and C4 [S]

Reference range, target level, or decision threshold

CH50 (total complement activity): 90-150 U/mL!!!

C3: 0.55-1.2 g/L!!!

C4: 0.2-0.5 g/L!!!

Interpretation of results

↑ Infections

↓ Congenital complement deficiency, liver diseases, complement consumption (activation by circulating immune complexes), SLE

We would love to hear from you

Comments, mistakes, suggestions?

Send feedback

Complement, Total (CH50), C3, and C4

Social Media