alpha-Fetoprotein (AFP)

How to Cite This Chapter: Don-Wauchope A, Chetty VT, Ivica J, Kavsak P, Khan WI, Lafreniere M, Nouri K, Solnica B. alpha-Fetoprotein (AFP). McMaster Textbook of Internal Medicine. Kraków: Medycyna Praktyczna. https://empendium.com/mcmtextbook/chapter/B31.1269.3.7.2. Accessed May 26, 2024.
Last Updated: May 9, 2022
Last Reviewed: May 9, 2022
Chapter Information

For a brief introduction and guide to abbreviations, see Laboratory Tests: General Remarks.

Analyte [material]

alpha-Fetoprotein (AFP) [S/P]

Reference range, target level, or decision threshold

<10 microg/L!!!

Reference intervals are different for infants.

Interpretation of results

↑ Hepatocellular carcinoma, nonseminomatous germ cell tumors, cholangiocarcinomas, hepatoblastoma, cirrhosis, viral hepatitis

Used to screen for open neural tube defect in pregnancy.

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