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McMaster Textbook of Internal Medicine

Mean Corpuscular Hemoglobin Concentration (MCHC)

How to Cite This Chapter: Don-Wauchope A, Chetty VT, Ivica J, Kavsak P, Khan WI, Lafreniere M, Nouri K, Solnica B. Mean Corpuscular Hemoglobin Concentration (MCHC). McMaster Textbook of Internal Medicine. Kraków: Medycyna Praktyczna. https://empendium.com/mcmtextbook/chapter/B31.1269.3.7.27.5. Accessed December 05, 2025.
Last Reviewed: May 9, 2022
Last Updated: May 9, 2022
Chapter Information

For a brief introduction and guide to abbreviations, see Laboratory Tests: General Remarks.

Analyte [material]

Mean corpuscular hemoglobin concentration (MCHC)

Reference range, target level, or decision threshold

32-36 g/dL of erythrocytes (20-22 mmol/L of erythrocytes)

Interpretation of results

↑ Hereditary spherocytosis (in autoimmune hemolytic anemia), cold agglutinin disease

↓ Hypochromia (mostly in iron deficiency anemia); decreased MCH and mean corpuscular hemoglobin concentration (MCHC) usually correspond with decreased mean corpuscular volume (MCV) (microcytosis)

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