Antithrombin (AT)

How to Cite This Chapter: Don-Wauchope A, Chetty VT, Ivica J, Kavsak P, Khan WI, Lafreniere M, Nouri K, Solnica B. Antithrombin (AT) Function. McMaster Textbook of Internal Medicine. Kraków: Medycyna Praktyczna. Accessed June 22, 2024.
Last Updated: May 9, 2022
Last Reviewed: May 9, 2022
Chapter Information

For a brief introduction and guide to abbreviations, see Laboratory Tests: General Remarks.

Analyte [material]

Antithrombin (AT) function [P]

Reference range, target level, or decision threshold

0.83-1.28 U/mL!!!; LD

AT immunoassay is also available as a specialty test.

Interpretation of results

↑ or falsely normal with direct factor Xa inhibitors for anti-Xa AT assays or with direct thrombin inhibitors for anti-IIa AT assays

↓ Congenital antithrombin deficiency, consumptive states (eg, acute thrombosis, DIC, sepsis), liver disease, nephrotic syndrome, malnutrition, protein-losing enteropathies, pregnancy, UFH treatment

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