Protein C and Protein S

Analyte [material]

Protein C [P], protein S [P]

Reference range, target level, or decision threshold

Protein C activity:! LD 70%-140% of normal or 0.70-1.40 IU/mL

Free protein S concentration:! LD

Men: 67%-139% or 0.74-1.46 IU/mL

Women: 60%-114% or 0.55-1.24 IU/mL

Interpretation of results

↓ Congenital or acquired deficiency due to vitamin K deficiency, treatment with vitamin K antagonists, liver diseases, acute thrombosis, disseminated intravascular coagulation, sepsis, protein S is also ↓ with pregnancy and other hyperestrogenic states, in nephrotic syndrome, and in those on L-asparaginase treatment